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18 Best Business Ideas in Missouri

Written by:

Esther is a business strategist with over 20 years of experience as an entrepreneur, executive, educator, and management advisor.

Edited by:

David has been writing and learning about business, finance and globalization for a quarter-century, starting with a small New York consulting firm in the 1990s.

18 Best Business Ideas in Missouri

Situated in the Mississippi River Valley, Missouri has a strong agricultural sector with nearly 100,000 farms, mostly family-owned. Besides agriculture, the state’s top industries are manufacturing, aerospace and defense, food, and energy. 

The Show-Me State has started to rebound from the pandemic, having recovered nearly all the jobs lost during the lockdowns. With brighter economic prospects, it’s a good time to launch your own business. Aside from setting up a farm, you can start a catering, vending machine, or retail business, to offer a few suggestions. Read on to learn about many more business ideas in Missouri.

1. Manufacturing

How to Start a Pallet Manufacturing Business

In Missouri, here are the steps that you need to follow to register a business and obtain necessary licenses. For example, if your business in based in St. Louis, you will need a manufacturer business license. Additionally, if your manufacturing involves environmental impact, permits from the Missouri Department of Natural Resources may be required.

A key tip is to connect with local manufacturing networks for insights and partnerships. Consider the logistics of your location—proximity to suppliers and distribution channels is crucial. Lastly, keep abreast of state regulations that affect manufacturing sectors.

2. Real Estate

how to start a real estate business

To operate a real estate business in Missouri, you must have a licensed real estate broker and adhere to the regulations enforced by the Missouri Real Estate Commission. It’s vital to understand local market trends and demographics. Networking with other real estate professionals and joining local associations can provide valuable insights and leads. Always stay informed about changes in property laws and market conditions to advise clients effectively.

3. Health Care

How to start a home health care business

Opening a health care facility requires compliance with both state and federal regulations, and you must register your business with the Missouri Department of Health & Senior Services. It’s crucial to ensure all staff are properly licensed and trained. Build relationships with local health practitioners and insurance providers. Focus on patient care quality and privacy, adhering strictly to HIPAA laws. A solid reputation in the community can be your best asset.

4. Graphic Design

How to start a graphic design business

Graphic designers in Missouri can operate with minimal formal licensing, but registering your business is recommended for tax purposes. Build a strong portfolio to attract a diverse clientele. Keep up with the latest software and design trends to stay competitive. Networking with local businesses and freelancers can lead to collaborations and new projects. Consider specializing to differentiate yourself in the market.

5. Insurance

How to start a insurance agency

To start an insurance agency, you need to be licensed by the Missouri Department of Commerce and Insurance. Stay updated with Missouri’s insurance regulations to maintain compliance. It’s important to understand the specific needs of the local population to offer relevant insurance products. Strong customer service and trustworthy advice are key to building a loyal client base. Utilize digital marketing to reach a wider audience effectively.

6. Solar Business

How to start a solar farm

Starting a solar business in Missouri requires understanding both state incentives and the federal tax credits available to customers. You must register your business and may need specific permits for installations. Focus on educating your community about the benefits of solar energy to drive sales. Partnering with local government and businesses can also open up new opportunities. Keep updated with technological advances in solar energy systems.

7. Recycling Business

How to start a recycling business

To open a recycling business, check with the Missouri Department of Natural Resources for necessary environmental permits. Understanding local material needs and focusing on how to efficiently process recyclable materials is essential. Establish connections with businesses that generate a large amount of recyclable waste. Educate the community on the benefits of recycling to encourage participation and supply.

8. Tax Preparer

tax preparer business idea

As a tax preparer in Missouri, you must comply with IRS regulations, including obtaining a Preparer Tax Identification Number (PTIN). It’s beneficial to become an IRS Enrolled Agent for credibility. Stay current with both federal and Missouri tax laws to provide accurate advice. Offering year-round financial services can help retain clients. Prioritize confidentiality and reliability in your services.

9. Freight Brokerage

How to Start a Freight Forwarding Business

Starting a freight brokerage in Missouri involves obtaining a USDOT number and a broker authority license from the Federal Motor Carrier Safety Administration. Understanding the logistics and transportation laws applicable in Missouri is crucial. Build a network of reliable carriers and maintain good relationships with them. Focus on efficient and cost-effective shipping solutions to attract and retain clients.

10. Blog

blog business idea

To start a blog in Missouri, no specific licenses are required, but it’s wise to register your business for tax purposes. Choose a niche that resonates with your interests and has a potential audience. Consistently produce high-quality, engaging content. Utilizing SEO effectively can help increase your visibility. Engage with your readers through comments and social media to build a community.

11. Candy Shop

How to start a candy store

Opening a candy shop in Missouri requires a sales tax license and adherence to health department regulations regarding food sales. Choose a location with high foot traffic like near schools or family-centered areas. Keep a diverse inventory that caters to both traditional tastes and unique, artisanal options. Seasonal promotions and community events can boost sales and visibility.

12. Catering

How to start a catering business

For a catering business in Missouri, you need to comply with health department regulations and obtain a food service license. Understanding your target market’s preferences and dietary needs is key. Offer menus that cater to a variety of events and budgets. Building strong relationships with local food suppliers can ensure freshness and reduce costs. Effective time management skills are essential for success.

13. Cake Making

How to start a cake business

To start a cake making business in Missouri, obtain a food service license. Creativity and skill in cake design are crucial. Stay updated with current trends in cake decoration and flavor profiles. Use social media platforms to showcase your designs and attract customers. Offering customization options can set you apart from competitors.

14. Retail Store

How to start a furniture store business

Opening a retail store in Missouri requires obtaining a sales tax license from the Missouri Department of Revenue. Choosing the right location is critical—consider demographics and foot traffic. Keep a diverse inventory that appeals to local tastes and preferences. Strong customer service and an inviting store layout can significantly enhance the shopping experience. Regular promotions and community involvement can help maintain customer interest.

15. Vending Machine

How to start a vending machine business

Operating vending machines in Missouri involves registering your business and obtaining a sales tax license. Location is the most important aspect; high-traffic areas such as schools, hospitals, office buildings, and malls are ideal. Keep your machines well-stocked and functioning. Offering a variety of products, including healthy options, can attract a broader clientele. Regular maintenance and cleanliness will keep customers coming back.

16. Farm

How to start a farm business

Starting a farm in Missouri requires registering your property and business. You may need specific permits depending on the type of farming (e.g., livestock or crop production). Knowledge of agricultural practices suited to the Missouri climate and soil is essential. Explore local and federal grants for farming. Building relationships with local markets and food companies can ensure steady sales channels.

17. Podcast

How to start a podcast

Starting a podcast in Missouri is straightforward, with no specific licenses required. Choose a niche that is both of interest to you and appealing to a broad audience. Consistently producing content and maintaining high audio quality are key factors. Use social media to promote your podcast and engage with listeners to build a loyal audience. Collaborations with other podcasters can also broaden your reach.

18. Wellness Center

How to start a spa business

Opening a wellness center in Missouri requires a business license and compliance with health department regulations. Certifications for offered services, such as yoga or massage, enhance credibility. Location should be serene and accessible. Offering a range of services and classes can cater to diverse client needs. Strong marketing and a focus on client well-being are crucial for growth and reputation.


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18 Best Business Ideas in Missouri